Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4765M)

Drug Name
Curcumin analog 1 Drug Info
Synonyms PMID26394986-Compound-32
Cross-matching ID
PubChem CID
11487078
CAS Number
CAS 52328-97-9
TTD Drug ID
DM4765M

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Inhibitor [1]
Signal transducer and activator of transcription 3 (STAT3) TTH8FZW STAT3_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Janus kinase 2 (JAK-2) DTT JAK2 4.957 5.257 4.986 4.784
Signal transducer and activator of transcription 3 (STAT3) DTT STAT3 9.537 8.097 9.732 8.128
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Janus kinase 2 (JAK-2) DTT JAK2 9.53E-04 0.27 1.44
Signal transducer and activator of transcription 3 (STAT3) DTT STAT3 6.12E-01 0.14 0.69
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421.