Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM48HVI)

Drug Name

JTT-551 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Type-2 diabetes	5A11	Terminated	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein-tyrosine phosphatase 1B (PTP1B)	TTMS7KP	PTN1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Protein-tyrosine phosphatase 1B (PTP1B)	DTT	PTPN1	3.667	2.293	2.609	4.573

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Type-2 diabetes

ICD Disease Classification

5A11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Protein-tyrosine phosphatase 1B (PTP1B)	DTT	PTPN1	9.44E-01	7.21E-03	0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice. J Diabetes Res. 2014;2014:680348.