Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM49AYM)

• Drug Name: S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea Drug Info
• Synonyms: TFPI hydrochloride; ETPI HCl; 163490-78-6; s-ethyl-n-[4-(trifluoromethyl)phenyl]isothiourea hydrochloride; S-Ethyl N-[4-Triflurormethyl)phenyl]isothio Urea, Hydrochloride; CHEMBL542855; SR-01000076170; EU-0101170; AC1MBZ30; C10H11F3N2S.HCl; SCHEMBL4425282; MolPort-027-641-133; 1762AH; NCGC00094428-04; NCGC00094428-03; NCGC00094428-02; NCGC00094428-01; FT-0668409; T 7188; J-010049; SR-01000076170-4; SR-01000076170-1; S-Ethyl N-[4-(trifluoromethyl)phenyl]isothiourea hydrochloride; ethyl 4-(trifluoromethyl)phenylcarbamimidothioate h

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3311
  CAS Number: CAS 163490-40-2
  TTD Drug ID: DM49AYM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	5.20E-01	0.02	0.07

References

• [1] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.