Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM49MYE)

Drug Name

PF-877423 Drug Info

Synonyms

PF-877423; CHEMBL1095047; N-Adamantan-2-Yl-1-Ethyl-D-Prolinamide; SCHEMBL5157584; UJRJQNDIYCDCNX-BAPHQMLMSA-N; BDBM50317209; N-2-adamantyl-1-ethyl-D-prolinamide; (2R)-N-(adamantan-2-yl)-1-ethylpyrrolidine-2-carboxamide; (1S,2R)-N-(2-adamantyl)-1-ethyl-pyrrolidine-2-carboxamide; 1-ethyl-N-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]-D-prolinamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11601544
TTD Drug ID: DM49MYE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	10.967	5.178	5.865	6.377

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	2.03E-01	-0.01	-0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2010 May 1;20(9):2897-902.