Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4BTH8)

Drug Name
GSK2330672 Drug Info
Indication
Disease Entry ICD 11 Status REF
Pruritus EC90 Phase 2 [1]
Type-2 diabetes 5A11 Phase 2 [2]
Cross-matching ID
PubChem CID
53492727
CAS Number
CAS 1345982-69-5
TTD Drug ID
DM4BTH8
VARIDT Drug ID
DR01120

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ileal sodium/bile acid cotransporter (SLC10A2) TTPI1M5 NTCP2_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Ileal sodium/bile acid cotransporter (SLC10A2) DTT SLC10A2 5.752 5.641 5.904 6.506
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Pruritus
ICD Disease Classification EC90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Ileal sodium/bile acid cotransporter (SLC10A2) DTT SLC10A2 2.54E-01 -0.06 -0.17
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem. 2013 Jun 27;56(12):5094-114.