Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4EGV0)

Drug Name
Linaclotide Drug Info
Synonyms Linaclotide (USAN)
Indication
Disease Entry ICD 11 Status REF
Irritable bowel syndrome DD91.0 Approved [1]
Cross-matching ID
PubChem CID
16158208
ChEBI ID
CHEBI:68551
CAS Number
CAS 851199-59-2
TTD Drug ID
DM4EGV0
ACDINA Drug ID
D00366

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Guanylyl cyclase C (GUCY2C) TTLDPRG GUC2C_HUMAN Activator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Guanylyl cyclase C (GUCY2C) DTT GUCY2C 4.542 7.698 3.797 7.565
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Irritable bowel syndrome
ICD Disease Classification DD91.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Guanylyl cyclase C (GUCY2C) DTT GUCY2C 9.52E-03 2.35 5.13
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5017).
2 Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26.