Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4FHQR)

Drug Name
Canfosfamide Drug Info
Synonyms Telcyta (TN)
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 3 [1]
Cross-matching ID
PubChem CID
5312109
ChEBI ID
CHEBI:135883
CAS Number
CAS 158382-37-7
TTD Drug ID
DM4FHQR

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutathione S-transferase P (GSTP1) TT40K12 GSTP1_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glutathione S-transferase P (GSTP1) DTT GSTP1 7.068 8.612 9.074 8.459
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glutathione S-transferase P (GSTP1) DTT GSTP1 4.46E-01 1.42E-02 0.03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). Biochemistry. 2013 Nov 12;52(45):8069-78.