Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4G6LJ)

Drug Name

N-phenethyl-2-phenylquinoline-4-carboxamide Drug Info

Synonyms

N-phenethyl-2-phenylquinoline-4-carboxamide; 2-Phenyl-quinoline-4-carboxylic acid phenethyl-amide; 65628-69-5; BAS 00329480; ChemDiv3_013317; AC1MIR97; Oprea1_331981; Oprea1_089083; CBDivE_013546; CHEMBL1278237; CTK1I2246; DTXSID50389216; MolPort-001-924-745; HMS1510N07; ZINC3036412; AKOS000577213; MCULE-8602191420; NCGC00320157-01; EU-0063663; AB01317027-02; SR-01000583017; SR-01000583017-1; BRD-K88997350-001-01-1; 4-Quinolinecarboxamide, 2-phenyl-N-(2-phenylethyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3100293
CAS Number: CAS 65628-69-5
TTD Drug ID: DM4G6LJ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuromedin-K receptor (TACR3)	TTBPGLU	NK3R_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neuromedin-K receptor (TACR3)	DTT	TACR3	3.406	4.248	2.982	1.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neuromedin-K receptor (TACR3)	DTT	TACR3	3.59E-01	0.04	0.12
Neuromedin-K receptor (TACR3)	DTT	TACR3	5.19E-01	-4.10E-03	-0.03

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor. J Med Chem. 2010 Nov 25;53(22):8080-8.