Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4HB7S)

Drug Name

N-(1-benzylpiperidin-4-yl)-3,5-dimethoxybenzamide Drug Info

Synonyms

CHEMBL214684; N-(1-benzylpiperidin-4-yl)-3,5-dimethoxybenzamide; MolPort-008-305-779; STK491511; BDBM50192158; ZINC16603986; AKOS003382300; MCULE-7382461624; ST50942897

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 14514271
TTD Drug ID: DM4HB7S

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanin-concentrating hormone receptor 1 (MCHR1)	TTX4RTB	MCHR1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Melanin-concentrating hormone receptor 1 (MCHR1)	DTT	MCHR1	4.392	4.823	5.433	5.725

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Melanin-concentrating hormone receptor 1 (MCHR1)	DTT	MCHR1	6.98E-01	-0.01	-0.04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5445-50.