Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4IABG)

Drug Name

PMID17480064C16 Drug Info

Synonyms

724711-21-1; 3fhr; 2jbp; 2jbo; P4O; Pyrrolopyridine, 16; Kinome_3179; 3r2y; GTPL8177; BDBM30185; ZINC16052855; AKOS027322581; DB08358; KB-19275; DB-013997; FT-0745988

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10389239
TTD Drug ID: DM4IABG

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MAPK-activated protein kinase 2 (MAPKAPK2)	TTMUG9D	MAPK2_HUMAN	Inhibitor	[1]
MAPK-activated protein kinase 3 (MAPKAPK3)	TTFS4VU	MAPK3_HUMAN	Inhibitor	[1]
MAPK-activated protein kinase 5 (MAPKAPK5)	TT3UJ7Z	MAPK5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
MAPK-activated protein kinase 5 (MAPKAPK5)	DTT	MAPKAPK5	3.982	5.603	5.823	6.501

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
MAPK-activated protein kinase 5 (MAPKAPK5)	DTT	MAPKAPK5	5.33E-03	0.87	1.37

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54.