Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4IAKR)

• Drug Name: MD-1100 Drug Info
• Synonyms: Linaclotide acetate; Linaclotide acetate (USAN); MM-416775

Indication

Disease Entry	ICD 11	Status	REF
Constipation	DD91.1	Approved	[1]
Irritable bowel syndrome	DD91.0	Phase 2	[2]

• Cross-matching ID:
  PubChem CID: 16158207
  CAS Number: CAS 851199-60-5
  TTD Drug ID: DM4IAKR

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Guanylyl cyclase C (GUCY2C)	TTLDPRG	GUC2C_HUMAN	Activator	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Guanylyl cyclase C (GUCY2C)	DTT	GUCY2C	4.542	7.698	3.797	7.565

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 13 Disease of the digestive system
• Disease Class: ICD-11: DD91 Irritable bowel syndrome
• The Studied Tissue: Rectal colon tissue
• The Studied Disease: Irritable bowel syndrome [ICD-11:DD91.0]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Guanylyl cyclase C (GUCY2C)	DTT	GUCY2C	2.18E-02	-0.31	-0.55

References

• [1] Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
• [2] Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.