Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4JG60)

Drug Name
9-benzyl-6-(4-methylpiperazin-1-yl)-9H-purine Drug Info
Synonyms CHEMBL594468; 9-benzyl-6-(4-methylpiperazin-1-yl)-9H-purine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
46228160
TTD Drug ID
DM4JG60

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H4 receptor (H4R) TTXJ178 HRH4_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Histamine H4 receptor (H4R) DTT HRH4 5.238 4.933 4.347 4.022
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histamine H4 receptor (H4R) DTT HRH4 1.32E-01 0.1 0.9
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem. 2009 Oct 15;17(20):7186-96.