Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4NGUL)

Drug Name

1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine Drug Info

Synonyms

1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine; CHEMBL496013; 1-benzyl-4-(4-phenylpiperazino)phthalazine; 320418-04-0; AC1O4EAW; Oprea1_653246; SCHEMBL13444952; KS-000031YH; ZINC1393434; BDBM50269040; AKOS005082019

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6404568
CAS Number: CAS 320418-04-0
TTD Drug ID: DM4NGUL

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Smoothened homolog (SMO)	TT8J1S3	SMO_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Smoothened homolog (SMO)	DTT	SMO	4.01E-06	-0.18	-0.35

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. J Med Chem. 2009 Jul 9;52(13):3954-68.