Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM50NKS)

Drug Name

N-hydroxy-2-(4-methoxyphenylsulfonamido)acetamide Drug Info

Synonyms

CHEMBL83508; N-Hydroxy-N~2~-[(4-Methoxyphenyl)sulfonyl]glycinamide; Hydroxamate 9; Z79; 3lk8; SCHEMBL7410575; BDBM11328; (4-Methoxyphenylsulfonylamino)acetohydroximic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10445302
TTD Drug ID: DM50NKS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-14 (MMP-14)	TTJ4QE7	MMP14_HUMAN	Inhibitor	[1]
TNF alpha converting enzyme (ADAM17)	TT6AZXG	ADA17_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Matrix metalloproteinase-14 (MMP-14)	DTT	MMP14	3.843	5.564	5.52	5.657
TNF alpha converting enzyme (ADAM17)	DTT	ADAM17	4.995	5.443	5.278	5.225

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
TNF alpha converting enzyme (ADAM17)	DTT	ADAM17	3.03E-08	0.15	0.45

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule sheddi... J Med Chem. 2010 Mar 25;53(6):2622-35.