Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5971G)

Drug Name
C4X-101 Drug Info
Synonyms TRH inhibitors (anxiety disorder/nutritional disorder/endocrine disease), Conformetrix
Indication
Disease Entry ICD 11 Status REF
Endocrine disease 5B3Z Investigative [1]
Cross-matching ID
TTD Drug ID
DM5971G

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thyrotropin-releasing hormone receptor (TRHR) TT4J8MF TRFR_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Thyrotropin-releasing hormone receptor (TRHR) DTT TRHR 3.406 1.632 1.678 1.485
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Endocrine disease
ICD Disease Classification 5B3Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Thyrotropin-releasing hormone receptor (TRHR) DTT TRHR 2.98E-01 0.11 0.61
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 363).