Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5JVAN)

Drug Name
Fingolimod Drug Info
Synonyms 2-Amino-2-(4-octylphenethyl)propane-1,3-diol
Indication
Disease Entry ICD 11 Status REF
Multiple sclerosis 8A40 Approved [1]
Primary progressive multiple sclerosis 8A40.1 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [3]
Cross-matching ID
PubChem CID
107970
ChEBI ID
CHEBI:63115
CAS Number
CAS 162359-55-9
TTD Drug ID
DM5JVAN
INTEDE Drug ID
DR0696
ACDINA Drug ID
D00276

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sphingosine-1-phosphate receptor 1 (S1PR1) TT9JZCK S1PR1_HUMAN Modulator [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 4F12 (CYP4F12) DED26GV CP4FC_HUMAN Approved [5]
Cytochrome P450 4F2 (CYP4F2) DE3GT9C CP4F2_HUMAN Approved [5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Sphingosine-1-phosphate receptor 1 (S1PR1) DTT S1PR1 6.829 6.89 6.853 5.959
Cytochrome P450 4F12 (CYP4F12) DME CYP4F12 8.561 7.549 3.263 9.186
Cytochrome P450 4F2 (CYP4F2) DME CYP4F2 9.269 3.446 3.655 8.828
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 08 Nervous system disease
Disease Class ICD-11: 8A40 Multiple sclerosis
The Studied Tissue Plasmacytoid dendritic cells
The Studied Disease Multiple sclerosis [ICD-11:8A40]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cytochrome P450 4F12 (CYP4F12) DME CYP4F12 4.68E-01 -5.96E-03 -2.58E-02
Cytochrome P450 4F2 (CYP4F2) DME CYP4F2 2.36E-01 -6.45E-02 -1.81E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2407).
3 ClinicalTrials.gov (NCT04280588) Fingolimod in COVID-19
4 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
5 CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos. 2011 Feb;39(2):191-8.