Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5K0EI)

Drug Name

Adamantan-1-yl-piperazin-1-yl-methanone Drug Info

Synonyms

1-(1-adamantylcarbonyl)piperazine; 29869-08-7; adamantanyl piperazinyl ketone; CHEMBL391335; piperazin-1-yl(tricyclo[3.3.1.1~3,7~]dec-1-yl)methanone; adamantan-1-yl-piperazin-1-yl-methanone; AC1Q5KAX; SCHEMBL1150471; CTK4G3954; DTXSID70589438; XAFSAELWLMDLKL-UHFFFAOYSA-N; MolPort-006-345-515; 1-(1-adamantanecarbonyl)piperazine; ALBB-024506; ZINC12343593; STL412114; BDBM50207783; SBB071957; BBL037233; AKOS009097513; MCULE-3925280273; ST072044; EN300-25317; AB00983558-01; piperazine, 1-(tricyclo[3.3.1.1~3,7~]dec-1-ylcarbonyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 17233943
CAS Number: CAS 29869-08-7
TTD Drug ID: DM5K0EI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	10.967	5.178	5.865	6.377

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	2.03E-01	-0.01	-0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43.