Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5LQHB)

Drug Name

Avacopan Drug Info

Synonyms

CCX-168

Indication

Disease Entry	ICD 11	Status	REF
Anca-associated vasculitis	4A44.A	Approved	[1]
Eosinophilic granulomatosis with polyangiitis	4A44.A2	Phase 2	[2]
Hereditary haemolytic anemia	3A10.3	Phase 2	[2]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C5a anaphylatoxin chemotactic receptor (C5AR1)	TTHXFA1	C5AR1_HUMAN	Antagonist	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
C5a anaphylatoxin chemotactic receptor (C5AR1)	DTT	C5AR1	7.076	6.411	6.338	6.217

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Anca-associated vasculitis

ICD Disease Classification

4A44.A

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C5a anaphylatoxin chemotactic receptor (C5AR1)	DTT	C5AR1	3.99E-01	1.19	0.77

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	FDA Approved Drug Products from FDA Official Website. 2021. Application Number: 214487.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of ChemoCentryx.