Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5VEN9)

Drug Name
Minnelide 001 Drug Info
Indication
Disease Entry ICD 11 Status REF
Gastric adenocarcinoma 2B72 Phase 1 [1]
Gastrointestinal cancer 2C11 Phase 1 [2]
Cross-matching ID
TTD Drug ID
DM5VEN9

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Heat shock protein 70 (HSP70) TTHYBIX HS71A_HUMAN; HS71B_HUMAN Modulator [3]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Gastric adenocarcinoma
ICD Disease Classification 2B72
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Heat shock protein 70 (HSP70) DTT HSPA1A; HSPA1B 1.03E-20 0.32 1.2
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT01927965) Study of Minnelide in Patients With Advanced GI Tumors. U.S. National Institutes of Health.
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.