Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5YHU2)

• Drug Name: Avoralstat Drug Info
• Synonyms: TUWMKPVJGGWGNL-UHFFFAOYSA-N; UNII-UX17773O15; UX17773O15; 918407-35-9; Avoralstat [INN]; 3-(2-((4-Carbamimidoylphenyl)carbamoyl)-4-ethenyl-5-methoxyphenyl)-6-((cyclopropylmethyl)carbamoyl)pyridine-2-carboxylic acid; 3-{2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl}-6-[(cyclopropylmethyl)carbamoyl]pyridine-2-carboxylic acid; SCHEMBL17513082; AKOS030629101; DB12120; CS-7551; 2-Pyridinecarboxylic acid, 3-(2-(((4-(aminoiminomethyl)phenyl)amino)carbonyl)-4-ethenyl-5-met

Indication

Disease Entry	ICD 11	Status	REF
Hereditary angioedema	4A00.14	Phase 2/3	[1]

• Cross-matching ID:
  PubChem CID: 86566678
  CAS Number: CAS 918407-35-9
  TTD Drug ID: DM5YHU2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kininogen (KNG1)	TTDJ4MY	KNG1_HUMAN	Inhibitor	[2]
Tissue kallikrein (KLK2)	TTJLNAW	KLK2_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tissue kallikrein (KLK2)	DTT	KLK2	2.945	2.807	2.744	3.336

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Hereditary angioedema
• ICD Disease Classification: 4A00.14

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tissue kallikrein (KLK2)	DTT	KLK2	2.30E-01	-0.02	-0.2

References

• [1] ClinicalTrials.gov (NCT02303626) 12-Week Safety and Efficacy Study of BCX4161 as an Oral Prophylaxis Against HAE Attacks. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)