Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM614BA)

Drug Name

Re-188-P-2045 Drug Info

Synonyms

Neotide; RE-P2045; Rhenium 188-P-2045; Rhenium-188-labeled peptide (lung cancer), Antisoma; Rhenium-188-labeled peptide (lung cancer), Bryan Oncor/ Antisoma

Indication

Disease Entry	ICD 11	Status	REF
Lung cancer	2C25.0	Phase 1/2	[1]

Cross-matching ID

TTD Drug ID: DM614BA

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Somatostatin receptor type 2 (SSTR2)	TTZ6T9E	SSR2_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Somatostatin receptor type 2 (SSTR2)	DTT	SSTR2	4.703	4.931	5.624	5.184

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Lung cancer

ICD Disease Classification

2C25.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Somatostatin receptor type 2 (SSTR2)	DTT	SSTR2	9.79E-07	-0.38	-0.65

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The somatostatin analog 188Re-P2045 inhibits the growth of AR42J pancreatic tumor xenografts. J Nucl Med. 2014 Dec;55(12):2020-5.