Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM67KWM)

Drug Name
LGD-5552 Drug Info
Synonyms LGD-5552; CHEMBL259820; SCHEMBL4166143
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
24816375
TTD Drug ID
DM67KWM

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Androgen receptor messenger RNA (AR mRNA) TTKPW01 ANDR_HUMAN Inhibitor [1]
Glucocorticoid receptor messenger RNA (GCR mRNA) TTOZRK6 GCR_HUMAN Inhibitor [1]
Mineralocorticoid receptor (MR) TT26PHO MCR_HUMAN Inhibitor [1]
Progesterone receptor (PGR) TTUV8G9 PRGR_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Progesterone receptor (PGR) DTT PGR 1.848 1.888 1.263 0.138
Glucocorticoid receptor messenger RNA (GCR mRNA) DTT NR3C1 7.153 7.278 7.017 7.331
Androgen receptor messenger RNA (AR mRNA) DTT AR 5.955 4.868 5.902 5.567
Mineralocorticoid receptor (MR) DTT NR3C2 5.85 7.414 6.42 7.379
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glucocorticoid receptor messenger RNA (GCR mRNA) DTT NR3C1 3.19E-02 0.54 1.67
Mineralocorticoid receptor (MR) DTT NR3C2 7.31E-01 -5.31E-04 -1.53E-03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9.