Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM68D3O)

Drug Name

PG-545 Drug Info

Synonyms

PG-457; PG-500; PG-501; PG-502; PG-503; PG-504; PG-505; PG-506; PG-507; PG-508; PG-509; PG-510; PG-511; PG-512; PG-513; PG-514;PG-536; PG-546; PG-547; PG-554; PG-562; PG-500 series (heparan sulfate mimetics), Progen

Indication

Disease Entry	ICD 11	Status	REF
Ocular disease	1F00.1Z	Phase 1	[1]

Cross-matching ID

PubChem CID: 57412324
CAS Number: CAS 1144492-69-2
TTD Drug ID: DM68D3O

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heparanase (HPSE)	TTR7GJO	HPSE_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Heparanase (HPSE)	DTT	HPSE	4.848	5.82	5.433	5.278

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Ocular disease

ICD Disease Classification

1F00.1Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Heparanase (HPSE)	DTT	HPSE	8.10E-01	0.19	0.23

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Br J Cancer. 2011 Feb 15;104(4):635-42.