Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM69YWS)

Drug Name

CGP-40215A Drug Info

Synonyms

Cgp-40215A; Cgp 40215A; Bis((3-(aminoiminomethyl)phenyl)methylene)carbonimidic dihydrazide trihydrochloride; Carbonimidic dihydrazide, bis((3-(aminoiminomethyl)phenyl)methylene)-, trihydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Pneumocystis pneumonia	CA40.20	Terminated	[1]

Cross-matching ID

PubChem CID: 9576797
CAS Number: CAS 126534-93-8
TTD Drug ID: DM69YWS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	6.747	6.763	7.033	6.593

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Pneumocystis pneumonia

ICD Disease Classification

CA40.20

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	4.41E-05	0.37	0.61

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.