Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6EFN2)

Drug Name

9-chlorobenzo[h]isoquinolin-1(2H)-one Drug Info

Synonyms

9-chlorobenzo[h]isoquinolin-1(2H)-one; CHEMBL248988; 919290-40-7; SCHEMBL4296798; CTK3H3900; DTXSID50475406; XSQDWQSZUGGKPF-UHFFFAOYSA-N; ZINC28955758; BDBM50223471; Benz[h]isoquinolin-1(2H)-one, 9-chloro-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11993732
CAS Number: CAS 919290-40-7
TTD Drug ID: DM6EFN2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Checkpoint kinase-1 (CHK1)	TTTU902	CHK1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Checkpoint kinase-1 (CHK1)	DTT	CHEK1	4.267	4.629	3.739	5.322

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Checkpoint kinase-1 (CHK1)	DTT	CHEK1	7.22E-191	1.43	4.74

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6280-5.