Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6R1XH)

Drug Name
2-[4-(2-Thienyl)phenyl]-4-methylmorpholin-2-ol Drug Info
Synonyms CHEMBL449619; GTPL3081; BDBM50253901; compound 5 [PMID: 18754614]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
25108103
TTD Drug ID
DM6R1XH

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Squalene synthetase (FDFT1) TTFQEO5 FDFT_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Squalene synthetase (FDFT1) DTT FDFT1 7.652 8.602 8.32 8.907
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Squalene synthetase (FDFT1) DTT FDFT1 7.85E-01 -0.09 -0.38
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5.