Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM74KIM)

Drug Name

KB-003 Drug Info

Synonyms

KB-002; Anti-GM-CSF mAb (autoimmune disease), Ludwig/KaloBios; Anti-GM-CSF mAb (inflammatory disease/rheumatoid arthritis/asthma), KaloBios

Indication

Disease Entry	ICD 11	Status	REF
Severe asthma	CA23	Phase 2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Granulocyte-macrophage colony-stimulating factor (CSF2)	TTNYZG2	CSF2_HUMAN	Not Available	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Granulocyte-macrophage colony-stimulating factor (CSF2)	DTT	CSF2	3.027	3.863	3.372	4.747

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Severe asthma

ICD Disease Classification

CA23

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Granulocyte-macrophage colony-stimulating factor (CSF2)	DTT	CSF2	2.36E-01	-0.06	-0.26

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT00995449) Study of KB003 In Biologics-Inadequate Rheumatoid Arthritis. U.S. National Institutes of Health.
2	US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast.