General Information of Drug (ID: DM74RMP)

Drug Name
1-phenyl-1H-indole-2,3-dione Drug Info
Synonyms
1-Phenylisatin; 723-89-7; 1-Phenylindoline-2,3-dione; 1-Phenyl-1H-indole-2,3-dione; 1-phenylindole-2,3-dione; 1H-Indole-2,3-dione, 1-phenyl-; 1-Phenyl-indole-2,3-dione; INDOLE-2,3-DIONE, 1-PHENYL-; NSC 100013; BRN 0164531; 1H-Indole-2,3-dione, 1-phenyl- (9CI); 1-phenyl-2,3-dihydro-1H-indole-2,3-dione; UWCPWBIMRYXUOU-UHFFFAOYSA-N; AE-641/30401023; N-Phenylisatin; SMR000131753; phenylisatin; phenylindoledione; Phenyl Isatin; N-phenyl isatin; 1-phenyl isatin; NSC100013; 1-Phenylisatin,98%; 1-Phenylisatin, 97%; Isatin-based compound,
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
12884
CAS Number
CAS 723-89-7
TTD Drug ID
DM74RMP

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Liver carboxylesterase (CES1) TTMF541 EST1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Liver carboxylesterase (CES1) DTT CES1 12.04 6.525 5.311 5.909
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Liver carboxylesterase (CES1) DTT CES1 3.82E-08 1.86 1.9
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.