Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM75OR8)

Drug Name

1,2-dicyclohexylethane-1,2-dione Drug Info

Synonyms

Ethanedione, dicyclohexyl-; 951-88-2; 1,2-dicyclohexylethane-1,2-dione; 1,2-Dicyclohexylethanedione; SCHEMBL3071715; CHEMBL235287; 1,2-Dione-Based Compound, 7; BDBM22850; CTK3G8986; DTXSID40473153; 1,2-dicyclohexyl-1,2-ethanedione; 1,2-dicyclohexyl-ethane-1,2-dione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11806279
CAS Number: CAS 951-88-2
TTD Drug ID: DM75OR8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34.