Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM78AJ1)

Drug Name

1-(pyridin-4-yl)piperazine Drug Info

Synonyms

1-(4-Pyridyl)piperazine; 1008-91-9; 1-(pyridin-4-yl)piperazine; 1-Pyridin-4-yl-piperazine; 4-Piperazinopyridine; 1-(4-pyridyl)-piperazine; 4-pyridylpiperazine; 1-pyridin-4-ylpiperazine; 1-(4-pyridyl) piperazine; PIPERAZINE, 1-(4-PYRIDINYL)-; MFCD00040745; 4-(1-piperazino)pyridine; 1-(4-pyridinyl)piperazine; CHEMBL339069; 4-(1-PIPERAZINYL)PYRIDINE; 1-[4-pyridyl]piperazine; EINECS 213-764-7; 4-pyridyl piperazine; (4-pyridyl)piperazine; PubChem22899; l-(4-pyridyl)piperazine; AC1Q4WUQ; N-(4-Pyridyl)piperazine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 70517
CAS Number: CAS 1008-91-9
TTD Drug ID: DM78AJ1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phospholipase D1 (PLD1)	TT3T17P	PLD1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phospholipase D1 (PLD1)	DTT	PLD1	5.358	5.213	5.027	6.159

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phospholipase D1 (PLD1)	DTT	PLD1	7.36E-01	0.08	0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privil... Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3.