Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM796RI)

• Drug Name: ZYAN1 Drug Info
• Synonyms: Desidustat; 1616690-16-4; UNII-Y962PQA4KS; Y962PQA4KS; 1,2-dihydroquinoline-3-carbonyl]glycine; N-[1-(cyclopropylmethoxy)-4-hydroxy-2-oxo-; 2-(1-(cyclopropylmethoxy)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid; ZYAN1 compound; Desidustat [INN]; SCHEMBL15846922; BCP29692; EX-A2999; s9699; ZB1514; CS-8034; BS-16050; HY-103227; A16921; 2-[[1-(cyclopropylmethoxy)-4-hydroxy-2-oxoquinoline-3-carbonyl]amino]acetic acid; Glycine, N-((1-(cyclopropylmethoxy)-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl)-; N-(1-(Cyclopropylmethoxy)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine

Indication

Disease Entry	ICD 11	Status	REF
Anaemia	3A90	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 75593290
  CAS Number: CAS 1616690-16-4
  TTD Drug ID: DM796RI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase (HPH)	TTJQFBG	NOUNIPROTAC	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
HIF-prolyl hydroxylase (HPH)	DTT	HPH	6.61	7.198	6.148	6.784

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Anaemia
• ICD Disease Classification: 3A90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
HIF-prolyl hydroxylase (HPH)	DTT	NO-GeName	7.70E-01	4.40E-03	0.02

References

• [1] Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.
• [2] Pharmacological Characterization of ZYAN1, a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia. Drug Res (Stuttg). 2016 Feb;66(2):107-12.