Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM79DSN)

Drug Name
ABTAA Drug Info
Indication
Disease Entry ICD 11 Status REF
Sepsis 1G40-1G41 Investigative [1]
Cross-matching ID
TTD Drug ID
DM79DSN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiopoietin 1 receptor (TEK) TT9VGXW TIE2_HUMAN Activator [1]
Angiopoietin-2 (ANGPT2) TTKLQTJ ANGP2_HUMAN Binder [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Angiopoietin-2 (ANGPT2) DTT ANGPT2 2.036 2.472 1.722 3.433
Angiopoietin 1 receptor (TEK) DTT TEK 5.194 5.051 6.613 4.982
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Sepsis
ICD Disease Classification 1G40-1G41
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Angiopoietin-2 (ANGPT2) DTT ANGPT2 3.47E-04 -0.31 -0.4
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci Transl Med. 2016 Apr 20;8(335):335ra55.