Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7HGX8)

Drug Name

aloisine Drug Info

Synonyms

IN1538; RP106

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclin-dependent kinase 2 (CDK2)	TT7HF4W	CDK2_HUMAN	Inhibitor	[2]
Focal adhesion kinase 2 (PTK2B)	TTTEFBV	FAK2_HUMAN	Inhibitor	[2]
Tyrosine-protein kinase ZAP-70 (ZAP-70)	TTUMHT8	ZAP70_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cyclin-dependent kinase 2 (CDK2)	DTT	CDK2	2.28E-06	0.12	0.19

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5923).
2	Identification of binding specificity-determining features in protein families. J Med Chem. 2012 Mar 8;55(5):1926-39.