Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7IHUK)

Drug Name

3-[7'-(Methoxy)-napht-2'-yl]-quinuclidine-2-ene Drug Info

Synonyms

CHEMBL478981; SCHEMBL2422138; KZWBNNXTWZPPPP-UHFFFAOYSA-N; BDBM50270302; 3-[7''-(Methoxy)-napht-2''-yl]-quinuclidine-2-ene; 3-(6-methoxy-2-naphthyl)-1-azabicyclo[2.2.2]oct-2-ene

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11550718
CAS Number: CAS 894079-46-0
TTD Drug ID: DM7IHUK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Squalene synthetase (FDFT1)	TTFQEO5	FDFT_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Squalene synthetase (FDFT1)	DTT	FDFT1	7.652	8.602	8.32	8.907

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Squalene synthetase (FDFT1)	DTT	FDFT1	7.85E-01	-0.09	-0.38

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother. 2007 Nov;51(11):4049-61.