Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7JFDO)

Drug Name
Recombinant von Willebrand factor/recombinant Factor VIII complex Drug Info
Synonyms Willebrand factor/recombinant Factor VIII complex; Recombinant von Willebrand factor/recombinant Factor VIII complex (von Willebrand disease)
Indication
Disease Entry ICD 11 Status REF
Von willebrand disease 3B12 Phase 3 [1]
Cross-matching ID
TTD Drug ID
DM7JFDO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor VIII (F8) TT1290U FA8_HUMAN Modulator [2]
von Willebrand factor (VWF) TT3SZBT VWF_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
von Willebrand factor (VWF) DTT VWF 3.459 8.185 6.67 8.541
Coagulation factor VIII (F8) DTT F8 7.637 6.9 7.644 6.975
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Von willebrand disease
ICD Disease Classification 3B12
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
von Willebrand factor (VWF) DTT VWF 2.96E-01 2.47 2.08
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes. PLoS One. 2015 Apr 23;10(4):e0124930.
2 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates. Transfus Med Hemother. 2009 December; 36(6): 409-418.