Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7M58P)

Drug Name

6-hydroxydopa quinone Drug Info

Synonyms

Topa quinone; topaquinone; 6-hydroxydopa quinone; L-topaquinone; 6-Hydroxydopaquinone; 2,4,5-trihydroxyphenylalanine quinone; 135791-48-9; 64192-68-3; 3-(6-hydroxy-3,4-dioxocyclohexa-1,5-dien-1-yl)-l-alanine; 5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE; (2S)-2-amino-3-(6-hydroxy-3,4-dioxocyclohexa-1,5-dien-1-yl)propanoic acid; o-Topaquinone; 6-Hydroxyphenylalanine-3,4-dione; L-topaquinone residue; 5-(2-CARBOXY-2-AMINOETHYL)-4-HYDROXY-1,2-BENZOQUINONE; AC1Q6BVC; AC1L3XGD; TPQ; 2',4',5'-topaquinone; SCHEMBL1781673

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 123871
ChEBI ID: CHEBI:36076
CAS Number: CAS 64192-68-3
TTD Drug ID: DM7M58P

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Membrane copper amine oxidase (AOC3)	TT7HC21	AOC3_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Membrane copper amine oxidase (AOC3)	DTT	AOC3	7.055	8.263	6.709	7.374

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Membrane copper amine oxidase (AOC3)	DTT	AOC3	8.36E-22	-1.03	-1.54

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.