Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7PT8R)

Drug Name
BioE-743 Drug Info
Indication
Disease Entry ICD 11 Status REF
Leigh syndrome 5C53.24 Phase 2 [1]
Pontocerebellar hypoplasia type 6 LD20.01 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM7PT8R

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Quinone reductase 1 (NQO1) TT8XK6L NQO1_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Quinone reductase 1 (NQO1) DTT NQO1 5.453 7.493 8.082 7.086
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Leigh syndrome
ICD Disease Classification 5C53.24
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Quinone reductase 1 (NQO1) DTT NQO1 2.05E-04 0.89 2.67
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)