Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7QK5C)

Drug Name

2-(4-bromo-2-(hydroxymethyl)phenoxy)acetic acid Drug Info

Synonyms

CHEMBL214655; 2-(4-bromo-2-(hydroxymethyl)phenoxy)acetic acid; 2-[4-bromo-2-(hydroxymethyl)phenoxy]acetic acid; AC1LHWL0; AH-487/41804565; SCHEMBL3201339; MolPort-002-091-532; ZINC470785; HMS1590C02; BDBM50200250; MCULE-6729250214; SR-01000266540

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 894151
TTD Drug ID: DM7QK5C

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin D2 receptor 2 (PTGDR2)	TTQDMX5	PD2R2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin D2 receptor 2 (PTGDR2)	DTT	PTGDR2	4.436	5.954	4.217	4.641

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin D2 receptor 2 (PTGDR2)	DTT	PTGDR2	6.11E-02	-0.15	-0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem. 2006 Nov 16;49(23):6638-41.