Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7RYL4)

Drug Name
FG-2216 Drug Info
Indication
Disease Entry ICD 11 Status REF
Kidney disease GC2Z Phase 2 [1]
Cross-matching ID
PubChem CID
6914666
CAS Number
CAS 223387-75-5
TTD Drug ID
DM7RYL4

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HIF-prolyl hydroxylase (HPH) TTJQFBG NOUNIPROTAC Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
HIF-prolyl hydroxylase (HPH) DTT HPH 6.61 7.198 6.148 6.784
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Kidney disease
ICD Disease Classification GC2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
HIF-prolyl hydroxylase (HPH) DTT NO-GeName 7.70E-01 4.40E-03 0.02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018242)
2 Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD