Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7UVOD)

Drug Name

DH97 Drug Info

Synonyms

DH 97; DH97; 343263-95-6; N-[2-(2-benzyl-1H-indol-3-yl)ethyl]pentanamide; N-(2-(2-Benzyl-1H-indol-3-yl)ethyl)pentanamide; Luzindole,N-pentanoyl; Tocris-1218; AC1MRF3Z; 220339-00-4; N-pentanoyl 2-benzyltryptamine; N-Pentanoyl-2-benzyltryptamine; SCHEMBL1626901; GTPL3366; CHEMBL1327247; CHEBI:92107; CTK8E7620; BDBM85384; DTXSID90392749; MolPort-003-983-554; HMS3267D11; ZINC2581407; BN0182; AKOS024456472; NCGC00025049-01; NCGC00025049-02; ACM343263956; RT-012298; FT-0763744; SR-01000597373; SR-01000597373-1; J-019556

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3467177
ChEBI ID: CHEBI:92107
TTD Drug ID: DM7UVOD

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melatonin receptor type 1A (MTNR1A)	TT0WAIE	MTR1A_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Melatonin receptor type 1A (MTNR1A)	DTT	MTNR1A	5.71E-01	-0.08	-0.54

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3366).
2	Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):522-8.