General Information of Drug (ID: DM7YGJO)

Drug Name
5-Mercapto-pentanoic acid Drug Info
Synonyms
5-sulfanylpentanoic Acid; 5-Mercaptopentanoic Acid; 30247-98-4; 5-Mercapto-pentanoic acid; Pentanoic acid, 5-mercapto-; CHEMBL294565; 5-mercaptovaleric acid; SCHEMBL204062; CTK1C0536; DTXSID90447945; GCIZMJUHGHGRNW-UHFFFAOYSA-N; MolPort-013-659-967; BDBM50127619; ZINC13519063; AKOS010615958
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10909614
CAS Number
CAS 30247-98-4
TTD Drug ID
DM7YGJO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate carboxypeptidase II (GCPII) TT9G4N0 FOLH1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glutamate carboxypeptidase II (GCPII) DTT FOLH1 6.894 4.758 5.651 9.837
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glutamate carboxypeptidase II (GCPII) DTT FOLH1 1.40E-09 2.08 2.21
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96.