Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8109D)

Drug Name

Oxazolidin-(2Z)-ylideneamine Drug Info

Synonyms

24665-93-8; amino oxazoline; 1,3-oxazolidin-2-imine; 4,5-dihydrooxazol-2-amine; Oxazolidin-(2Z)-ylideneamine; 2-oxazolamine, 4,5-dihydro-; 4,5-dihydro-1,3-oxazol-2-amine; CHEMBL69446; aminooxazoline; iminooxazolidine; NSC43138; 2-amino-2-oxazoline; AC1Q4UHD; AC1L61HW; 2-amino-4,5-dihydrooxazole; 2-Oxazolamine,4,5-dihydro-; CTK4F4142; DTXSID50285885; MolPort-023-198-771; YAXGBZDYGZBRBQ-UHFFFAOYSA-N; MolPort-006-013-450; BDBM50078037; NSC-43138; ZINC13588690; AKOS006221228; AKOS009159127; NE22687; MCULE-9912511107; AJ-64218; AJ-64217

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 238663
CAS Number: CAS 24665-93-8
TTD Drug ID: DM8109D

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.95	5.198	4.573	5.121

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.24E-02	-0.27	-0.88

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6.