Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM81D90)

Drug Name

4-bromo-1H-indazole Drug Info

Synonyms

4-bromo-1H-indazole; 186407-74-9; 4-Bromoindazole; 1H-Indazole, 4-bromo-; 4-BROMO (1H)INDAZOLE; 4-Bromo(1H)indazole; CHEMBL246393; 4-bromo-indazole; bromo-1h-indazole; PubChem7834; 4-bromo-2H-indazole; ACMC-1BZDS; 4-bromanyl-1H-indazole; KSC173Q8P; 4-BROMO-7AH-INDAZOLE; SCHEMBL155255; 4-Bromo-1H-indazole, 95%; IND084; AC1Q24I6; Jsp003814; 4-bromo-1h-indazole, 97+%; SCHEMBL16799950; CTK0H3887; HID1021; DTXSID30625169; KJIODOACRIRBPB-UHFFFAOYSA-N; MolPort-022-450-748; MolPort-000-002-423; BCP00013; ACN-S003168; SBB054645; BDBM50209241

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 22352548
CAS Number: CAS 186407-74-9
TTD Drug ID: DM81D90

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	5.20E-01	0.02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80.