Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM81DTC)

Drug Name

6-Benzenesulfonyl-2H-pyridazin-3-one Drug Info

Synonyms

6-(benzenesulfonyl)-2,3-dihydropyridazin-3-one; 141060-78-8; 3(2H)-Pyridazinone, 6-(phenylsulfonyl)-; AC1Q6GZS; CHEMBL74814; SCHEMBL7295107; BDBM16442; ZICCKDUVBPQRQT-UHFFFAOYSA-N; MolPort-007-599-834; ZINC11536236; AKOS001782098; MCULE-8830355611; NE56517; 6-phenylsulfonylpyridazin-2H-3-one, 1; 6-phenylsulfonyl-3-oxo-2,3-dihydropyridazine; EN300-72670

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11701437
TTD Drug ID: DM81DTC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Aldose reductase (AKR1B1)	DTT	AKR1B1	7.436	8.652	9.874	8.066

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Aldose reductase (AKR1B1)	DTT	AKR1B1	1.08E-20	0.94	1.58

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39.