Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM84GAQ)

• Drug Name: 20-hydroxy-LTB4 Drug Info
• Synonyms: 20-Hydroxy-leukotriene B4; 20-hydroxy-LTB4; 20-hydroxy LTB4; 20-OH-LTB4; 20-OH-Leukotriene B4; (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid; CHEBI:15646; 79516-82-8; 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; 20-hydroxyleukotriene B4; (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoic acid; (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoate; (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate; 5,12,20-Trihete; w-Hydroxy-LTB4

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5280745
  ChEBI ID: CHEBI:15646
  CAS Number: CAS 79516-82-8
  TTD Drug ID: DM84GAQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leukotriene B4 receptor 2 (LTB4R2)	TTVJX54	LT4R2_HUMAN	Agonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Leukotriene B4 receptor 2 (LTB4R2)	DTT	LTB4R2	0.926	3.459	2	2.406

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Leukotriene B4 receptor 2 (LTB4R2)	DTT	LTB4R2	1.26E-01	0.04	0.15

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3399).
• [2] A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 1997 Jun 5;387(6633):620-4.