Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8A5E0)

• Drug Name: Vecabrutinib Drug Info
• Synonyms: UNII-PQ7O0OB5GU; PQ7O0OB5GU; Vecabrutinib [INN]; BIIB-062; SCHEMBL16765727; BSK-4841; FP-182; 1510829-06-7

Indication

Disease Entry	ICD 11	Status	REF
B-cell lymphoma	2A86	Phase 1/2	[1]

• Cross-matching ID:
  PubChem CID: 72547837
  CAS Number: CAS 1510829-06-7
  TTD Drug ID: DM8A5E0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine-protein kinase BTK (ATK)	TTGM6VW	BTK_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosine-protein kinase BTK (ATK)	DTT	BTK	3.838	3.897	5.053	5.897

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: B-cell lymphoma
• ICD Disease Classification: 2A86

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosine-protein kinase BTK (ATK)	DTT	BTK	3.54E-01	0.24	0.56

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)