Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8AM60)

Drug Name

TC-5214 Drug Info

Synonyms

Dexmecamylamine; DEXMECAMYLAMINE; UNII-5Y1141YI4U; 107538-05-6; 5Y1141YI4U; TC 5214; (1R,2S,4S)-N,2,3,3-Tetramethylbicyclo(2.2.1)heptan-2-amine; Dexmecamylamine [USAN:INN]; Dexmecamylamine (USAN); CHEMBL2103881; BDBM50045047; ZINC43763856; DB11807; D10111; UNII-6EE945D3OK component IMYZQPCYWPFTAG-NGZCFLSTSA-N; Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-, (1R,2S,4S)-

Indication

Disease Entry	ICD 11	Status	REF
Palmar hyperhidrosis	EE00.00	Phase 2	[1]

Cross-matching ID

PubChem CID: 12358971
CAS Number: CAS 107596-30-5
TTD Drug ID: DM8AM60

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4)	TT35UGH	ACHA3_HUMAN-ACHB4_HUMAN	Antagonist	[1]
Neuronal acetylcholine receptor beta-2 (CHRNB2)	TT5KPZR	ACHB2_HUMAN	Antagonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neuronal acetylcholine receptor beta-2 (CHRNB2)	DTT	CHRNB2	4.678	3.907	5.096	5.87

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Palmar hyperhidrosis

ICD Disease Classification

EE00.00

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neuronal acetylcholine receptor beta-2 (CHRNB2)	DTT	CHRNB2	7.10E-08	-0.15	-0.85

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)