Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8FSPV)

Drug Name
JTZ-951 Drug Info
Indication
Disease Entry ICD 11 Status REF
Anaemia 3A90 Phase 3 [1]
Cross-matching ID
PubChem CID
50899324
CAS Number
CAS 1262132-81-9
TTD Drug ID
DM8FSPV

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HIF-prolyl hydroxylase (HPH) TTJQFBG NOUNIPROTAC Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
HIF-prolyl hydroxylase (HPH) DTT HPH 6.61 7.198 6.148 6.784
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Anaemia
ICD Disease Classification 3A90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
HIF-prolyl hydroxylase (HPH) DTT NO-GeName 7.70E-01 4.40E-03 0.02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT04027517) A Study to Evaluate Efficacy and Safety of JTZ-951 Compared to Darbepoetin Alfa in Korean Renal Anemia Patients Receiving Hemodialysis.. U.S. National Institutes of Health.
2 DOI: 10.1038/nrneph.2015.82