Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8HLO5)

Drug Name

Canakinumab Drug Info

Synonyms

Ilaris (TN)

Indication

Disease Entry	ICD 11	Status	REF
Autosomal dominant familial periodic fever		Approved	[1]
Cryopyrin-associated periodic syndromes	4A60.1	Approved	[2]
Rheumatoid arthritis	FA20	Approved	[2]
Urticaria	EB00-EB05	Phase 2	[2]
Vasculitis	4A44	Phase 2	[2]
Familial Mediterranean fever		Investigative	[3]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Interleukin-1 beta (IL1B)	DTT	IL1B	6.757	6.019	6.475	7.026

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Autosomal dominant familial periodic fever

ICD Disease Classification

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin-1 beta (IL1B)	DTT	IL1B	3.05E-01	0.06	0.26

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes. N Engl J Med. 2018 May 17;378(20):1908-1919.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6773).
3	Familial Mediterranean fever, from pathogenesis to treatment: a contemporary review. Turk J Med Sci. 2020 Nov 3;50(SI-2):1591-1610.
4	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.