Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8NARQ)

Drug Name
1,3-Dibenzyl-[1,3]diazetidine-2,4-dione Drug Info
Synonyms CHEMBL47394; 1,3-dibenzyl-1,3-diazetidine-2,4-dione; GTPL6542; BDBM50101132; compound 1 [PMID: 11425539]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10038543
TTD Drug ID
DM8NARQ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin G (CTSG) TTQAJF1 CATG_HUMAN Inhibitor [1]
Cationic trypsinogen (PRSS1) TT2WR1T TRY1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Cathepsin G (CTSG) DTT CTSG 4.293 5.031 4.65 4.781
Cationic trypsinogen (PRSS1) DTT PRSS1 3.217 4.018 1.585 3.121
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cathepsin G (CTSG) DTT CTSG 1.80E-01 -0.43 -1.03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1691-4.